Specifications
Species Reactivity
Human; Mouse
Applications
Application Notes
WB (1:200-1:500); Immunofluorescence (1:200-1:500) & The optimal working dilution should be determined by the end user.
Target
Alternative Names
TERF2; telomeric repeat binding factor 2; TRBF2; telomeric repeat-binding factor 2; TRF2; telomeric DNA-binding protein; TTAGGG repeat-binding factor 2; telomeric repeat binding protein 2;
Product Background
Antigen Description
This gene encodes a telomere specific protein, TERF2, which is a component of the telomere nucleoprotein complex. This protein is present at telomeres in metaphase of the cell cycle, is a second negative regulator of telomere length and plays a key role in the protective activity of telomeres. While having similar telomere binding activity and domain organization, TERF2 differs from TERF1 in that its N terminus is basic rather than acidic.
Pathway
Cell Cycle, organism-specific biosystem; Chromosome Maintenance, organism-specific biosystem; Meiosis, organism-specific biosystem; Meiotic Synapsis, organism-specific biosystem; Packaging Of Telomere Ends, organism-specific biosystem; Regulation of Telomerase, organism-specific biosystem; Shelterin complex, organism-specific biosystem;
Citations
Publication ()
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COA
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