Anti-TEC (aa 311-410) polyclonal antibody

Species Reactivity

Human

Immunogen

TEC (NP_003206, 311 a.a. ~ 410 a.a) partial recombinant protein with GST tag. The sequence is KYYLAEKHAFGSIPEIIEYHKHNAAGLVTRLRYPVSVKGKNAPTTAGFSYEKWEINPSEL TFMRELGSGLFGVVRLGKWRAQYKVAIKAIREGAMCEEDF

Conjugate

Alternative Names

TEC; tec protein tyrosine kinase; PSCTK4; tyrosine-protein kinase Tec;

Entrez Gene ID

UniProt ID

Antigen Description

The protein encoded by this gene belongs to the Tec family of non-receptor protein-tyrosine kinases containing a pleckstrin homology domain. Tec family kinases are involved in the intracellular signaling mechanisms of cytokine receptors, lymphocyte surface antigens, heterotrimeric G-protein coupled receptors, and integrin molecules. They are also key players in the regulation of the immune functions. Tec kinase is an integral component of T cell signaling and has a distinct role in T cell activation. This gene may be associated with myelodysplastic syndrome.

Pathway

B Cell Receptor Signaling Pathway; EPO signaling pathway; Fc epsilon receptor (FCERI) signaling; IL-6 Signaling Pathway