Anti-TEC monoclonal antibody, clone Z409

Antibody Isotype

IgG

Clone

Z409

Species Reactivity

Mouse; Rat; Human

Immunogen

A synthetic peptide corresponding to residues in the PH domain of human Tec

Conjugate

Application Notes

WB: 1/2000 - 1/5000; ICC: 1/100 - 1/250; Flow Cyt: 1/30 - 1/100; IP: 1/50;

Alternative Names

TEC; tec protein tyrosine kinase; tyrosine-protein kinase Tec; PSCTK4; MGC126760; MGC126762;

Entrez Gene ID

UniProt ID

Antigen Description

The protein encoded by this gene belongs to the Tec family of non-receptor protein-tyrosine kinases containing a pleckstrin homology domain. Tec family kinases are involved in the intracellular signaling mechanisms of cytokine receptors, lymphocyte surface antigens, heterotrimeric G-protein coupled receptors, and integrin molecules. They are also key players in the regulation of the immune functions. Tec kinase is an integral component of T cell signaling and has a distinct role in T cell activation. This gene may be associated with myelodysplastic syndrome.

Pathway

B Cell Receptor Signaling Pathway, organism-specific biosystem; Cytokine Signaling in Immune system, organism-specific biosystem; EPO signaling pathway, organism-specific biosystem; IL-3 Signaling Pathway, organism-specific biosystem; IL-6 Signaling Pathway, organism-specific biosystem; Immune System, organism-specific biosystem; Interleukin-3, 5 and GM-CSF signaling, organism-specific biosystem;