Anti-TEAD2 (aa 238-249) polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

Synthetic peptide: C-EPPDAVDSYQRH, corresponding to internal amino acids 238 - 249 of Human TEA domain family member 2 (NP_003589.1).

Conjugate

Application Notes

WB: Use at a concentration of 1 - 3 μg/ml. Detects a band of approximately 50 kDa (predicted molecular weight: 49 kDa).

Alternative Names

TEAD2; TEA domain family member 2; ETF; TEF4; TEF-4; TEAD-2; transcriptional enhancer factor TEF-4;

Entrez Gene ID

UniProt ID

Antigen Description

Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds to the SPH and GT-IIC enhansons (5-GTGGAATGT-3). May be involved in the gene regulation of neural development. Binds to the M-CAT motif.

Pathway

Fatty acid, triacylglycerol, and ketone body metabolism; Generic Transcription Pathway; Hippo signaling pathway; Metabolism of lipids and lipoproteins