Anti-TEAD2 (aa 2-51) polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

Synthetic peptide corresponding to a region within N terminal amino acids 2-51 (GEPRAGAALD DGSGWTGSEE GSEEGTGGSE GAGGDGGPDA EGVWSPDIEQ) of Human TEA domain family member 2 (NP_003589)

Conjugate

Application Notes

WB: 1 μg/ml;Peptide ELISA: 1/12500;

Alternative Names

TEAD2; TEA domain family member 2; ETF; TEF4; TEF-4; TEAD-2; transcriptional enhancer factor TEF-4;

Entrez Gene ID

UniProt ID

Antigen Description

Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds to the SPH and GT-IIC enhansons (5-GTGGAATGT-3). May be involved in the gene regulation of neural development. Binds to the M-CAT motif.

Pathway

Fatty acid, triacylglycerol, and ketone body metabolism; Generic Transcription Pathway; Hippo signaling pathway; Metabolism of lipids and lipoproteins