Anti-TEAD1 monoclonal antibody, clone FQS6380

Antibody Isotype

IgG

Clone

FQS6380

Species Reactivity

Mouse; Rat; Human

Immunogen

Synthetic peptide corresponding to residues on the C-terminus in Human TEF1.

Conjugate

Application Notes

WB: 1/10000 - 1/50000; Flow Cyt: 1/100 - 1/500;

Alternative Names

TEAD1; TEA domain family member 1 (SV40 transcriptional enhancer factor); AA, atrophia areata, peripapillary chorioretinal degeneration , TCF13; transcriptional enhancer factor TEF-1; TEF 1; protein GT-IIC; transcription factor 13; transcriptional enhanc

Entrez Gene ID

UniProt ID

Antigen Description

Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and cooperatively to the SPH and GT-IIC enhansons (5-GTGGAATGT-3) and activates transcription in vivo in a cell-specific manner. The activation function appears to be mediated by a limiting cell-specific transcriptional intermediary factor (TIF). Involved in cardiac development. Binds to the M-CAT motif.

Pathway

Fatty acid, triacylglycerol, and ketone body metabolism, organism-specific biosystem; Gene Expression, organism-specific biosystem; Generic Transcription Pathway, organism-specific biosystem; Metabolism, organism-specific biosystem; Metabolism of lipids and lipoproteins, organism-specific biosystem; PPARA Activates Gene Expression, organism-specific biosystem; Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha), organism-specific biosystem;