Anti-TEAD1 (aa 361-410) polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

Synthetic peptide corresponding to a region within C terminal amino acids 361-410 (MMNSVLENFT ILLVVTNRDT QETLLCMACV FEVSNSEHGA QHHIYRLVKD) of Human TEF1 (NP_068780).

Conjugate

Application Notes

WB: 0.25 μg/ml; IHC-P: 5 - 16 μg/ml;

Alternative Names

TEAD1; TEA domain family member 1 (SV40 transcriptional enhancer factor); AA; REF1; TCF13; TEF-1; NTEF-1; TCF-13; TEAD-1; transcriptional enhancer factor TEF-1; protein GT-IIC; transcription factor 13; transcriptional enhancer factor 1;

Entrez Gene ID

UniProt ID

Antigen Description

Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and cooperatively to the SPH and GT-IIC enhansons (5-GTGGAATGT-3) and activates transcription in vivo in a cell-specific manner. The activation function appears to be mediated by a limiting cell-specific transcriptional intermediary factor (TIF). Involved in cardiac development. Binds to the M-CAT motif.

Pathway

Fatty acid, triacylglycerol, and ketone body metabolism; Generic Transcription Pathway; Hippo signaling pathway; Metabolism of lipids and lipoproteins