Anti-TCF7L1 (aa 489-586) polyclonal antibody

Species Reactivity

Human

Immunogen

TCF7L1 (NP_112573, 489 a.a. ~ 586 a.a) partial recombinant protein with GST tag. The sequence is PAAPAATHSEQAQPLSLTTKPETRAQLALHSAAFLSAKAAASSSGQMGSQPPLLSRPLPL GSMPTALLASPPSFPATLHAHQALPVLQAQPLSLVTKS

Conjugate

Alternative Names

TCF7L1; transcription factor 7-like 1 (T-cell specific, HMG-box); TCF3; TCF-3; transcription factor 7-like 1; HMG box transcription factor 3;

Entrez Gene ID

UniProt ID

Antigen Description

This gene encodes a member of the T cell factor/lymphoid enhancer factor family of transcription factors. These transcription factors are activated by beta catenin, mediate the Wnt signaling pathway and are antagonized by the transforming growth factor beta signaling pathway. The encoded protein contains a high mobility group-box DNA binding domain and participates in the regulation of cell cycle genes and cellular senescence.

Pathway

Acute myeloid leukemia; Adherens junction; Arrhythmogenic right ventricular cardiomyopathy; Arrhythmogenic right ventricular cardiomyopathy (ARVC)