Specifications
Immunogen
Synthetic peptide corresponding to residues in Human TCF7L1 (UniProt Q9HCS4).
Applications
Application Notes
WB: 1/1000 - 1/5000; Flow Cyt: 1/100;
Target
Alternative Names
TCF7L1; transcription factor 7-like 1 (T-cell specific, HMG-box); TCF3; transcription factor 7-like 1; HMG box transcription factor 3; TCF-3;
Product Background
Antigen Description
Participates in the Wnt signaling pathway. Binds to DNA and acts as a repressor in the absence of CTNNB1, and as an activator in its presence. Necessary for the terminal differentiation of epidermal cells, the formation of keratohyalin granules and the development of the barrier function of the epidermis (By similarity). Down-regulates NQO1, leading to increased mitomycin c resistance.
Pathway
Acute myeloid leukemia, organism-specific biosystem; Acute myeloid leukemia, conserved biosystem; Adherens junction, organism-specific biosystem; Adherens junction, conserved biosystem; Arrhythmogenic right ventricular cardiomyopathy (ARVC), organism-specific biosystem; Arrhythmogenic right ventricular cardiomyopathy (ARVC), conserved biosystem; Basal cell carcinoma, organism-specific biosystem;
Citations
Publication ()
Have you cited DCABH-2698 in a publication?
Let us know and earn a reward for your research.
COA
Loading ......
