Rabbit Anti-Human TCF7 (internal) Polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human; Mouse

Immunogen

Synthetic peptide corresponding to a region derived from internal residues of human transcription factor 7 (T-cell specific, HMG-box)

Conjugate

Application Notes

WB: 1:200-1:1000

General Notes

This product (Catalog No. DPABH-14520) is a rabbit-derived IgG polyclonal antibody raised against human TCF7. This antibody exhibits cross-reactivity with TCF7 from mouse. It has been affinity purified by protein A. This gene encodes a member of the T-cell factor/lymphoid enhancer-binding factor family of high mobility group (HMG) box transcriptional activators. This gene is expressed predominantly in T-cells and plays a critical role in natural killer cell and innate lymphoid cell development. The encoded protein forms a complex with beta-catenin and activates transcription through a Wnt/beta-catenin signaling pathway. Mice with a knockout of this gene are viable and fertile, but display a block in T-lymphocyte differentiation. Alternative splicing results in multiple transcript variants. Naturally-occurring isoforms lacking the N-terminal beta-catenin interaction domain may act as dominant negative regulators of Wnt signaling.
DPABH-14520 is suitable for use in Western blot (WB) (1:200–1:1,000) application.
DPABH-14520 is supplied as a liquid formulation in pH7.4 PBS, 0.05% sodium azide, 40% Glycerol. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.

Alternative Names

TCF-1

Entrez Gene ID

UniProt ID