TCF7 (NP_003193, 287 a.a. ~ 384 a.a) partial recombinant protein with GST tag. The sequence is VIAECTLKESAAINQILGRRWHALSREEQAKYYELARKERQLHMQLYPGWSARDNYGKKK RRSREKHQESTTGGKRNAFGTYPEKAAAPAPFLPMTVL
The protein encoded by this gene is a transcriptional activator that plays an important role in lymphocyte differentiation. This gene is expressed predominantly in T-cells. The encoded protein can bind an enhancer element and activate the CD3E gene, and it also may repress the CTNNB1 and TCF7L2 genes through a feedback mechanism. Several transcript variants encoding different isoforms have been found for this gene.
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