Synthetic peptide, corresponding to a region within C terminal amino acids 224-273 (TAEEMASDEL KEMRKNLTKE AIREHQMAKT GGTQTDLFTC GKCKKKNCTY) of Rat TCEA1 (NP_001020906).
Conjugate
Unconjugated
Applications
Application Notes
WB: 1 μg/ml.
Target
Alternative Names
TCEA1; transcription elongation factor A (SII) 1; transcription elongation factor A protein 1; transcription elongation factor S-II protein 1; MGC116288;
Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3-terminus.
Pathway
DNA Repair; Dual incision reaction in TC-NER; Formation of RNA Pol II elongation complex; Formation of transcription-coupled NER (TC-NER) repair complex; Gene Expression; Nucleotide Excision Repair; RNA Polymerase II Pre-transcription Events
Citations
Publication ()
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COA
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