Anti-TCEA1 monoclonal antibody, clone FQS26147-27

Antibody Isotype

IgG

Clone

FQS26147-27

Species Reactivity

Mouse; Rat; Human

Immunogen

Recombinant fragment within Human TCEA1 aa 1-150 (N terminal). The exact sequence is proprietary.Database link: P23193

Conjugate

Application Notes

WB: 1/10000 - 1/50000; IP: 1/60 - 1/80; ICC/IF: 1/250;

Alternative Names

TCEA1; transcription elongation factor A (SII), 1; GTF2S, TCEA; transcription elongation factor A protein 1; SII; TF2S; TFIIS; transcription elongation factor TFIIS.o; transcription elongation factor S-II protein 1; TCEA; GTF2S;

Entrez Gene ID

UniProt ID

Antigen Description

Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3-terminus.

Pathway

DNA Repair, organism-specific biosystem; Disease, organism-specific biosystem; Dual incision reaction in TC-NER, organism-specific biosystem; Formation of HIV-1 elongation complex containing HIV-1 Tat, organism-specific biosystem; Formation of HIV-1 elongation complex in the absence of HIV-1 Tat, organism-specific biosystem; Formation of RNA Pol II elongation complex, organism-specific biosystem; Formation of transcription-coupled NER (TC-NER) repair complex, organism-specific biosystem;