Anti-TAF1C (aa 819-869) polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

Synthetic peptide, corresponding to a region within amino acids 819-869 of Human TAF1C (NP_005670.3).

Conjugate

Application Notes

WB: 1/2000 - 1/10000; IP: 2-10 μg/mg lysate.

Alternative Names

TAF1C; TATA box binding protein (TBP)-associated factor, RNA polymerase I, C, 110kDa; TATA box binding protein (TBP) associated factor, RNA polymerase I, C, 110kD; TATA box-binding protein-associated factor RNA polymerase I subunit C; MGC:39976; SL1; TAFI

Entrez Gene ID

UniProt ID

Antigen Description

Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (preinitiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits. Recruits RNA polymerase I to the rRNA gene promoter via interaction with RRN3.

Pathway

Gene Expression; RNA Polymerase I Chain Elongation; RNA Polymerase I Promoter Clearance; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription; RNA Polymerase I Transcription Initiation; RNA Polymerase I Transcription Termination