Anti-TAF1C monoclonal antibody, clone FQS22309

Antibody Isotype

IgG

Clone

FQS22309

Species Reactivity

Human

Immunogen

Synthetic peptide (the amino acid sequence is considered to be commercially sensitive) within Human TAF1C aa 800 to the C-terminus (Cysteine residue). The exact sequence is proprietary.Database link: Q15572

Conjugate

Application Notes

WB: 1/1000 - 1/5000; IP: 1/10 - 1/100;

Alternative Names

TAF1C; TATA box binding protein (TBP)-associated factor, RNA polymerase I, C, 110kDa; TATA box binding protein (TBP) associated factor, RNA polymerase I, C, 110kD; TATA box-binding protein-associated factor RNA polymerase I subunit C; MGC:39976; SL1; TAFI

Entrez Gene ID

UniProt ID

Antigen Description

Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (preinitiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits. Recruits RNA polymerase I to the rRNA gene promoter via interaction with RRN3.

Pathway

Gene Expression, organism-specific biosystem; RNA Polymerase I Chain Elongation, organism-specific biosystem; RNA Polymerase I Promoter Clearance, organism-specific biosystem; RNA Polymerase I Promoter Escape, organism-specific biosystem; RNA Polymerase I Transcription, organism-specific biosystem; RNA Polymerase I Transcription Initiation, organism-specific biosystem; RNA Polymerase I Transcription Termination, organism-specific biosystem;