Ca2+plays a critical role in intracellular signaling and thus regulationof calcium balance is critical for the maintenance of this signaling function. The plasmamembrane Na+/Ca2+(NaCX) exchangers mediate Na+-dependent Ca2+efflux in a wide variety ofcell types. NaCX can move Ca2+either into or out of cells, depending on the net Na+, Ca2+, andK+gradient across the membrane. In mammals, at least 5 distinct genes code for theexchangers: Three NaCX (NaCX-1, NaCX-2, and NaCX-3), and two in the NaCKX family(NaCKX-1 and NaCKX-2). NaCX-1 is most prominently expressed in the heart where it plays amajor role in excitation-contraction coupling. NACX-1 may also be atarget for protection of the heart and brain fromischemia and reperfusion injury.
Pathway
Adrenergic signaling in cardiomyocytes; Arrhythmogenic right ventricular cardiomyopathy (ARVC); Calcium Regulation in the Cardiac Cell; Calcium signaling pathway; Cardiac muscle contraction; Dilated cardiomyopathy; Endocrine and other factor-regulated calcium reabsorption; Hemostasis;
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