ZNF384-fusion proteins have high affinity for the transcriptional coactivator EP300 and aberrant transcriptional activities
FEBS LETTERS
Authors: Yamamoto, Hideyuki; Hayakawa, Fumihiko; Yasuda, Takahiko; Odaira, Koya; Minamikawa, Yuka; Tange, Naoyuki; Hirano, Daiki; Kojima, Yuki; Morishita, Takanobu; Tsuzuki, Shinobu; Naoe, Tomoki; Kiyoi, Hitoshi
Abstract
Zinc-finger protein 384 (ZNF384) fusion (Z-fusion) genes have recently been identified as recurrent fusion genes in B-cell precursor acute lymphoblastic leukaemia (BCP-ALL) and have been detected in 7-17% of Philadelphia chromosome-negative BCP-ALL cases. We selected SALL4 and ID2 as potential Z-fusion-specific transcriptional targets that might lead to the differentiation disorder of Z-fusion-positive ALL. The introduction of EP300-ZNF384 and SYNRG-ZNF384 induced the expression of these genes. Z-fusion proteins exhibited stronger transcriptional activities on the promoter or enhancer region of these genes than Wild-Z. Furthermore, GST pull-down assay revealed that Z-fusion proteins associated more strongly with EP300 than Wild-Z. Coexpression of EP300 specifically enhanced the transcriptional activities of Z-fusion proteins. We propose the increased EP300 binding of Z-fusion proteins as a mechanism for their increased transcriptional activities.
Standalone and Grid Connected Operations of a SynRG based WECS with BESS
2018 IEEMA ENGINEER INFINITE CONFERENCE (ETECHNXT)
Authors: Vijay, Deepu M.; Singh, Bhim; Bhuvaneswari, G.
Abstract
This work advocates an effective way of energy management in a microgrid consisting of a synchronous reluctance generator (SynRG) based wind energy conversion system (WECS) connected to a DC bus, which voltage is maintained by a battery energy storage system (BESS). The system is capable of feeding a fairly constant value of power to the grid apart from supplying the local loads. Apart from maintaining the DC link voltage, the BESS compensates for the fluctuations in the wind power by channelizing the power in and out of the BESS as per the power generation and power demand. The SynRG is operated in direct torque control (DTC) mode corresponding to maximum power point (MPP) of the WECS by adjusting the control inputs to the machine side converter. The battery in BESS, is integrated to the DC bus using a bidirectional converter (BDC), which helps in charging and discharging of the battery. A voltage source converter (VSC) connected on the grid side evacuates the power from the common DC link and feeds it to the three-phase grid. This VSC is controlled in such a way as to maintain the required power factor on the grid side as per the reference values of the direct and quadrature axes components of currents specified. The proposed system is designed, modeled and simulated in Simulink/ MATLAB environment.
COA
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