SYNJ2 (NP_003889, 1396 a.a. ~ 1495 a.a) partial recombinant protein with GST tag. The sequence is GTKAMKPEAAPLLGDYQDPFWNLLHHPKLLNNTWLSKSSDPLDSGTRSPKRDPIDPVSAG ASAAKAELPPDHEHKTLGHWVTISDQEKRTALQVFDPLAK
The gene is a member of the inositol-polyphosphate 5-phosphatase family. The encoded protein interacts with the ras-related C3 botulinum toxin substrate 1, which causes translocation of the encoded protein to the plasma membrane where it inhibits clathrin-mediated endocytosis. Alternative splicing results in multiple transcript variants.
Pathway
1D-myo-inositol hexakisphosphate biosynthesis II (mammalian); D-myo-inositol (1,3,4)-trisphosphate biosynthesis; Inositol phosphate metabolism; Metabolism of lipids and lipoproteins
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