Specifications
Species Reactivity
Mouse; Rat; Cow; Dog; Human
Immunogen
Synthetic peptide: C-DAFISENGWVEDY, corresponding to C terminal amino acids 291-303 of Human STUB1.
Applications
Application Notes
ELISA: 1/32000; WB: 0.3 - 1 μg/ml; IHC-P: 2.5 - 3.75 μg/ml.
Target
Alternative Names
STUB1; STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase; STIP1 homology and U box containing protein 1; E3 ubiquitin-protein ligase CHIP; CHIP; HSPABP2; NY CO 7; SDCCAG7; UBOX1; antigen NY-CO-7; CLL-associated antigen KW-8; serol
Product Background
Antigen Description
E3 ubiquitin-protein ligase which targets misfolded chaperone substrates towards proteasomal degradation. Ubiquitinates NOS1 in concert with Hsp70 and Hsp40. Modulates the activity of several chaperone complexes, including Hsp70, Hsc70 and Hsp90. Mediates transfer of non-canonical short ubiquitin chains to HSPA8 that have no effect on HSPA8 degradation. Mediates polyubiquitination of DNA polymerase beta (POLB) at Lys-41, Lys-61 and Lys-81, thereby playing a role in base-excision repair: catalyzes polyubiquitination by amplifying the HUWE1/ARF-BP1-dependent monoubiquitination and leading to POLB-degradation by the proteasome. Mediates polyubiquitination of CYP3A4.
Pathway
Adaptive Immune System; Alpha-synuclein signaling; Androgen Receptor Signaling Pathway; Antigen processing: Ubiquitination & Proteasome degradation; Class I MHC mediated antigen processing & presentation
Citations
Publication ()
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COA
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