Anti-STUB1 monoclonal antibody, clone 26

Antibody Isotype

IgG1

Clone

26

Species Reactivity

Human

Immunogen

Recombinant full length protein corresponding to Human STUB1 aa 1-303. Expressed in E.coli.Sequence: MKGKEEKEGGARLGAGGGSPEKSPSAQELKEQGNRLFVGRKYPEAAACYG RAITRNPLVAVYYTNRALCYLKMQQHEQALADCRRALELDGQSVKAHFFL GQCQLEMESYDEAIANLQRAYSLAKEQRLNFGDDIPSALRIAKKKRWNSI E

Conjugate

Application Notes

WB: 1/1000;

Alternative Names

STUB1; STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase; STIP1 homology and U box containing protein 1; E3 ubiquitin-protein ligase CHIP; CHIP; HSPABP2; NY CO 7; SDCCAG7; UBOX1; antigen NY-CO-7; CLL-associated antigen KW-8; serol

Entrez Gene ID

UniProt ID

Antigen Description

E3 ubiquitin-protein ligase which targets misfolded chaperone substrates towards proteasomal degradation. Ubiquitinates NOS1 in concert with Hsp70 and Hsp40. Modulates the activity of several chaperone complexes, including Hsp70, Hsc70 and Hsp90. Mediates transfer of non-canonical short ubiquitin chains to HSPA8 that have no effect on HSPA8 degradation. Mediates polyubiquitination of DNA polymerase beta (POLB) at Lys-41, Lys-61 and Lys-81, thereby playing a role in base-excision repair: catalyzes polyubiquitination by amplifying the HUWE1/ARF-BP1-dependent monoubiquitination and leading to POLB-degradation by the proteasome. Mediates polyubiquitination of CYP3A4.

Pathway

Adaptive Immune System, organism-specific biosystem; Alpha-synuclein signaling, organism-specific biosystem; Androgen Receptor Signaling Pathway, organism-specific biosystem; Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystem; Class I MHC mediated antigen processing & presentation, organism-specific biosystem;