Anti-STK24 (aa 125-189) polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

Synthetic peptide containing a sequence corresponding to a region within amino acids 125-189 (LREILKGLDY LHSEKKIHRD IKAANVLLSE HGEVKLADFG VAGQLTDTQI KRNTFVGTPF WMAPE) of Human MST3 (NP_001027467).

Conjugate

Application Notes

WB: 1/500 - 1/3000; ICC/IF: 1/100 - 1/200;

Alternative Names

STK24; serine/threonine kinase 24; MST3; STK3; MST3B; STE20; HEL-S-95; serine/threonine-protein kinase 24; STE20-like kinase 3; STE20-like kinase MST3; sterile 20-like kinase 3; epididymis secretory protein Li 95; mammalian STE20-like protein kinase 3; se

Entrez Gene ID

UniProt ID

Antigen Description

Serine/threonine-protein kinase that acts on both serine and threonine residues and promotes apoptosis in response to stress stimuli and caspase activation. Mediates oxidative-stress-induced cell death by modulating phosphorylation of JNK1-JNK2 (MAPK8 and MAPK9), p38 (MAPK11, MAPK12, MAPK13 and MAPK14) during oxidative stress. Plays a role in a staurosporine-induced caspase-independent apoptotic pathway by regulating the nuclear translocation of AIFM1 and ENDOG and the DNase activity associated with ENDOG. Phosphorylates STK38L on Thr-442 and stimulates its kinase activity. Regulates cellular migration with alteration of PTPN12 activity and PXN phosphorylation: phosphorylates PTPN12 and inhibits its activity and may regulate PXN phosphorylation through PTPN12. May act as a key regulator of axon regeneration in the optic nerve and radial nerve.

Pathway

Apoptosis; Apoptotic execution phase;