Anti-STAM monoclonal antibody

Antibody Isotype

IgG1

Species Reactivity

Human

Immunogen

Recombinant full length protein, corresponding to amino acids 1-404 of Human STAM1

Conjugate

Application Notes

IHC-P: 3 μg/ml; WB: 1 - 5 μg/ml.

Alternative Names

STAM; signal transducing adaptor molecule (SH3 domain and ITAM motif) 1; signal transducing adapter molecule 1; HSE1 homolog (S. cerevisiae); STAM1; HSE1 homolog; STAM-1; DKFZp686J2352;

Entrez Gene ID

UniProt ID

Antigen Description

Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes.

Pathway

Disease, organism-specific biosystem; EGFR downregulation, organism-specific biosystem; ESCRT-0 complex, organism-specific biosystem; Endocytosis, organism-specific biosystem; Endocytosis, conserved biosystem; Endosomal Sorting Complex Required For Transport (ESCRT), organism-specific biosystem; IL-2 Signaling Pathway, organism-specific biosystem;