Anti-STAM monoclonal antibody, clone H2H6

Antibody Isotype

IgG1

Clone

H2H6

Species Reactivity

Mouse; Rat; Human

Immunogen

Full length protein corresponding to Mouse STAM aa 1-523.Sequence: MPLFTANPFEQDVEKATNEYNTTEDWSLIMDICDRVGSTPSGAKDCLKAI MKRVNHKVPH VALQALTLLGACVANCGKIFHLEVCSRDFATEVRSVIK NKAHPKVCEKLKSLMVEWSEEF QKDPQFSLISATIKSMKEEGVTFPSA GSQTVAAAAKNGTSLNKNKEDEDIAKAIELSLQE QK

Conjugate

Application Notes

IHC-P: 1/500; WB: 1/1000.

Alternative Names

STAM; signal transducing adaptor molecule (SH3 domain and ITAM motif) 1; signal transducing adapter molecule 1; STAM-1; STAM1;

Entrez Gene ID

UniProt ID

Antigen Description

Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes.

Pathway

Disease, organism-specific biosystem; EGFR downregulation, organism-specific biosystem; ESCRT-0 complex, organism-specific biosystem; Endocytosis, organism-specific biosystem; Endocytosis, conserved biosystem; IL-2 Signaling Pathway, organism-specific biosystem; IL-4 signaling Pathway, organism-specific biosystem;