Synthetic peptide: VQNMALYADV GGKQFPVTRG QDVGRYQVSW SLDHKSAHAG TYEVRFFDEE SYSLLRKAQR , corresponding to amino acids 61 - 130 of Human Signal sequence receptor delta
Conjugate
Unconjugated
Applications
Application Notes
WB: 1/2000;
Target
Alternative Names
SSR4; signal sequence receptor, delta; TRAPD; translocon-associated protein subunit delta; SSR-delta; TRAP-delta; translocon-associated protein delta; signal sequence receptor subunit delta;
Signal sequence receptor delta is assumed to be involved in protein secretion. It is located in the Xq28 region, arranged in a compact head-to-head manner with the IDH3G gene. These two genes are driven by a bidirectional promoter located between them, and encode proteins involved in unrelated biochemical pathways located in different compartments of the cell. The nontranscribed intergenic region represents only 133 bp and is embedded in a CpG island. The CpG island functions as a bidirectional promoter to initiate the transcription of both functionally unrelated genes with distinct expression patterns. Signal sequence receptor delta consists of six exons and is approximately 70 kb telomeric to the ALD gene. Although alternative splicing of exon 5 has not been detected in human Signal sequence receptor delta, transcript variants missing the region homologous to human exon 5 have been detected in both Xenopus laevis and Mus musculus.
Pathway
Gene Expression; Protein processing in endoplasmic reticulum; SRP-dependent cotranslational protein targeting to membrane; Translocon-associated protein (TRAP) complex
Custom Antibody Labeling
We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More
Citations
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Holm, D; Fink, DR; et al. Characterization of a novel human scavenger receptor cysteine-rich molecule SCART1 expressed by lymphocytes. IMMUNOBIOLOGY 218:408-417(2013).
Haynes, MR; Wu, GE; et al. Evolution of the variable gene segments and recombination signal sequences of the human T-cell receptor alpha/delta locus. IMMUNOGENETICS 56:470-479(2004).
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COA
Certificate of Analysis
