Coupling pre-mRNA splicing and 3 ' end formation to mRNA export: alternative ways to punch the nuclear export clock
GENES & DEVELOPMENT
Authors: Elbarbary, Reyad A.; Maquat, Lynne E.
Abstract
How does a mammalian cell determine when newly synthesized mRNAs are fully processed and appropriate for nuclear export? Muller-McNicoll and colleagues (pp. 553-566) expand on mechanisms known to be mediated by nuclear export factor 1 (NXF1) by describing SR proteins as NXF1 adaptors that flag alternatively spliced and polyadenylated mRNA isoforms as cargo ready for the cytoplasm.
Polymorphisms in alternative splicing associated genes are associated with lung cancer risk in a Chinese population
LUNG CANCER
Authors: Shen, Wei; Yin, Rong; Wang, Cheng; Zhu, Meng; Zhou, Wen; Qin, Na; Sun, Jie; Liu, Jia; Dong, Jing; Jin, Guangfu; Ma, Hongxia; Hu, Zhibin; Shen, Hongbing; Xu, Lin; Dai, Juncheng
Abstract
Background: Alternative splicing is an important biological step during mRNA processing. Misregulation of alternative splicing can produce aberrant protein isoforms, thus contributing to cancer. We hypothesized that variants in 5 critical splicing factor-associated genes might play an important role in carcinogenesis of lung cancer. Materials and methods: A case-control study including 1,341 non-small cell lung cancer (NSCLC) cases and 1,982 cancer-free controls were conducted to evaluate the associations of 16 tagging/functional polymorphisms in 5 splicing factor-associated genes with lung cancer risk. Results: We found altogether 8 SNPs were associated with lung cancer risk with adjustment of age, gender, and smoking status after multiple corrections (FDR). Among these, six SNPs were related with SRSF7(rs10197412, OR(95%CI)=1.23(1.06-1.43), P for FDR=0.018; rs12621103, OR(95%CI)=1.25(1.08-1.46), P for FDR=0.016; rs13024811, OR(95%CI)=1.25(1.07-1.46), P for FDR=0.016; rs2037875, OR(95%CI)=1.23(1.06-1.42), P for FDR=0.018; rs3134628, OR(95%CI)=1.25(1.07-1.45), P for FDR=0.016 and rs6715866, OR(95%CI)=1.23(1.07-1.43), P for FDR=0.016); one SNP was near PTBP2 (rs12566237: OR(95%CI)=1.16(1.05-1.28), P for FDR=0.016) and one SNP in HNRNPQ(rs16876385: OR(95%CI)=1.17(1.04-1.32), P for FDR=0.022). Conclusions: Our findings indicated that genetic variants in these splicing-associated genes might modify individual susceptibility to lung cancer in Chinese population. Further large-scale well-formed population studies and functional researches are warranted to confirm our findings. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
COA
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