This gene belongs to a family of Sp1 related genes that encode transcription factors that regulate transcription by binding to consensus GC- and GT-box regulatory elements in target genes. This protein contains a zinc finger DNA-binding domain and several transactivation domains, and has been reported to function as a bifunctional transcription factor that either stimulates or represses the transcription of numerous genes. Transcript variants encoding different isoforms have been described for this gene, and one has been reported to initiate translation from a non-AUG (AUA) start codon. Additional isoforms, resulting from the use of alternate downstream translation initiation sites, have also been noted.
Pathway
Regulation of Telomerase, organism-specific biosystem; Selenium Metabolism and Selenoproteins, organism-specific biosystem;
Citations
Publication ()
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References
Nickel- catalysed alkylation of C( sp3)- H bonds with alcohols: direct access to functionalised N- heteroaromatics
The first base-metal catalysed coupling of primary alcohols with methyl-N-heteroaromatics is reported. The use of an earth abundant and nonprecious NiBr2/L1 system enables access to a series of C(sp(3))-alkylated N-heteroaromatics. Mechanistic studies have established the participation of a hydrogen-borrowing strategy for -alkylation.
Fractal Patterns in Long-term Behavior of GPS and GLONASS Orbits
2019 INTERNATIONAL SIBERIAN CONFERENCE ON CONTROL AND COMMUNICATIONS (SIBCON)
Authors: Ovchinnikova, Elena V.; Tsarev, Sergey P.
In this paper we analyze repetitive patterns in GLONASS and GPS satellite orbits for the time span of 1 year using fractal dimension computation. A number of different statistical phenomena for such repetitive patterns at various dimension scales are reported. As we demonstrate Moll, the expected local dimension 6 does not hold for 1-year sets of GNSS satellite orbits, these sets have much smaller dimensions. The histograms of distributions of the orbit clusters collected in the process of computation of the fractal dimension shim remarkable "resonances" for some special values of the box size.