SOST, also known as sclerostin, is a member of the Cerberus/DAN family of BMP antagonists, a group of secreted glycoproteins characterized by a cysteine-knot motif. SOST is expressed by osteoclasts in developing bones of mouse embryos, including both intramembranously forming skull bones and endochondrally forming long bones.
Pathway
Signal Transduction; Signaling by Wnt; TCF dependent signaling in response to WNT; Wnt signaling pathway; negative regulation of TCF-dependent signaling by WNT ligand antagonists;
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