Mouse myeloma cell line NS0-derived recombinant human SOST/Sclerostin. Gln24-Tyr213 Accession Number Q9BQB4
Conjugate
Unconjugated
Applications
Application Notes
Western Blot: 1 μg/mL; ELISA Capture: 2-8 μg/mL; ELISA Detection: 0.5-2.0 μg/mL We recommend the following for sandwich ELISA (Capture - Detection): DCABY-4007 - DCABY-4285
SOST, also known as sclerostin, is a member of the Cerberus/DAN family of BMP antagonists, a group of secreted glycoproteins characterized by a cysteine-knot motif. SOST is expressed by osteoclasts in developing bones of mouse embryos, including both intramembranously forming skull bones and endochondrally forming long bones.
Pathway
Signal Transduction; Signaling by Wnt; TCF dependent signaling in response to WNT; Wnt signaling pathway; negative regulation of TCF-dependent signaling by WNT ligand antagonists;
Citations
Publication ()
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