SOS1 (NP_005624, 313 a.a. ~ 420 a.a) partial recombinant protein with GST tag. The sequence is SQLSKPGAALYLQSIGEGFKEAVQYVLPRLLLAPVYHCLHYFELLKQLEEKSEDQEDKEC LKQAITALLNVQSGMEKICSKSLAKRRLSESACRFYSQQMKGKQLAIK
Conjugate
Unconjugated
Target
Alternative Names
SOS1; son of sevenless homolog 1 (Drosophila); GF1; HGF; NS4; GGF1; GINGF; son of sevenless homolog 1; SOS-1; guanine nucleotide exchange factor; gingival fibromatosis, hereditary, 1;
This gene encodes a protein that is a guanine nucleotide exchange factor for RAS proteins, membrane proteins that bind guanine nucleotides and participate in signal transduction pathways. GTP binding activates and GTP hydrolysis inactivates RAS proteins. The product of this gene may regulate RAS proteins by facilitating the exchange of GTP for GDP. Mutations in this gene are associated with gingival fibromatosis 1 and Noonan syndrome type 4.
Pathway
Activation of Rac; Acute myeloid leukemia; Alcoholism; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Citations
Publication ()
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