Anti-SNX9 monoclonal antibody, clone FQS25400 Knockout Validated

Antibody Isotype

IgG

Clone

FQS25400

Species Reactivity

Mouse; Rat; Human

Immunogen

Recombinant fragment within Human SH3PX1 aa 50-200. The exact sequence is proprietary.Database link: Q9Y5X1

Conjugate

Application Notes

WB: 1/1000 - 1/10000; IHC-P: 1/100 - 1/250; ICC/IF: 1/100; Flow Cyt: 1/10; IP: 1/50.

Alternative Names

SNX9; sorting nexin 9; sorting nexin-9; SDP1; SH3PX1; SH3PXD3A; SH3 and PX domain-containing protein 1; SH3 and PX domain-containing protein 3A; SH3 and PX domain-containing protein SH3PX1; Wiskott-Aldrich syndrome protein (WASP) interactor protein; WISP;

Entrez Gene ID

UniProt ID

Antigen Description

May be involved in several stages of intracellular trafficking. Plays a role in endocytosis via clathrin-coated pits, but also clathrin-independent, actin-dependent fluid-phase endocytosis. Plays a role in macropinocytosis. Promotes internalization of TNFR. Promotes degradation of EGFR after EGF signaling. Stimulates the GTPase activity of DNM1. Promotes DNM1 oligomerization. Promotes activation of the Arp2/3 complex by WASL, and thereby plays a role in the reorganization of the F-actin cytoskeleton. Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate and promotes membrane tubulation. Has lower affinity for membranes enriched in phosphatidylinositol 3-phosphate.

Pathway

Clathrin derived vesicle budding, organism-specific biosystem; Golgi Associated Vesicle Biogenesis, organism-specific biosystem; Membrane Trafficking, organism-specific biosystem; trans-Golgi Network Vesicle Budding, organism-specific biosystem;