Anti-SLC6A5 monoclonal antibody, clone FQS21859

Antibody Isotype

IgG

Clone

FQS21859

Species Reactivity

Mouse; Rat; Human

Immunogen

A synthetic peptide corresponding to residues in Human Glyt2.

Conjugate

Application Notes

WB: 1/1000 - 1/10000.

Alternative Names

SLC6A5; solute carrier family 6 (neurotransmitter transporter, glycine), member 5; NET1; sodium- and chloride-dependent glycine transporter 2; GLYT2; GLYT-2;

Entrez Gene ID

UniProt ID

Antigen Description

Human glutamate receptor delta-2 (GRID2) is a relatively new member of the family of ionotropic glutamate receptors which are the predominant excitatory neurotransmitter receptors in the mammalian brain.GRID2 is a predicted 1,007 amino acid protein that shares 97% identity with the mouse homolog which is expressed selectively in cerebellar Purkinje cells.A point mutation in mouse GRID2, associated with the phenotype named lurcher, in the heterozygous state leads to ataxia resulting from selective, cell-autonomous apoptosis of cerebellar Purkinje cells during postnatal development. Mice homozygous for this mutation die shortly after birth from massive loss of mid- and hindbrain neurons during late embryogenesis.This strongly suggests a role for GRID2 in neuronal apoptotic death.

Pathway

Na+/Cl- dependent neurotransmitter transporters, organism-specific biosystem; SLC-mediated transmembrane transport, organism-specific biosystem; Transmembrane transport of small molecules, organism-specific biosystem; Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds, organism-specific biosystem.