Anti-SLC29A4 monoclonal antibody, clone 7C7

Antibody Isotype

IgG2a

Clone

7C7

Species Reactivity

Human; Rat

Immunogen

SLC29A4 (NP_694979, 283 a.a. ~ 345 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Conjugate

Alternative Names

SLC29A4; solute carrier family 29 (nucleoside transporters), member 4; equilibrative nucleoside transporter 4; ENT4; FLJ34923; hENT4; solute carrier family 29 member 4; plasma membrane monoamine transporter; PMAT;

Entrez Gene ID

UniProt ID

Antigen Description

This gene is a member of the SLC29 family and encodes a plasma membrane protein with 11 transmembrane helices. This protein catalyzes the reuptake of monoamines into presynaptic neurons, thus determining the intensity and duration of monoamine neural signaling. It has been shown to transport several compounds, including serotonin, dopamine, and the neurotoxin 1-methyl-4-phenylpyridinium. Alternate transcriptional splice variants which encode the same protein have been characterized.

Pathway

SLC-mediated transmembrane transport, organism-specific biosystem; Transmembrane transport of small molecules, organism-specific biosystem; Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane, organism-specific biosystem; Transport of vitamins, nucleosides, and related molecules, organism-specific biosystem;