Mediates both influx and efflux of nucleosides across the membrane (equilibrative transporter). It is sensitive (ES) to low concentrations of the inhibitor nitrobenzylmercaptopurine riboside (NBMPR) and is sodium-independent. It has a higher affinity for adenosine. Inhibited by dipyridamole and dilazep (anticancer chemotherapeutics drugs).
Pathway
Alcoholism; Fluoropyrimidine Activity; Transmembrane transport of small molecules; Transport of vitamins, nucleosides, and related molecules
Citations
Publication ()
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