EAAT4 is expressed predominantly in the cerebellum (Purkinje cells) and weakly in the forebrain, where it transports L-glutamate, L-aspartate and D-aspartate, acting as a symport by cotransporting sodium. EAAT4 may function as a combined transporter and inhibitory glutamate receptor and also functions as an anion-selective ion channel.
Pathway
Glutamate Neurotransmitter Release Cycle; Glutamatergic synapse; Neurotransmitter Release Cycle; Transmembrane transport of small molecules
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