Anti-SIN3A monoclonal antibody, clone FQS7880

Antibody Isotype

IgG

Clone

FQS7880

Species Reactivity

Human

Immunogen

Synthetic peptide corresponding to residues in Human mSin3A.

Conjugate

Application Notes

WB: 1/1000 - 1/10000; ICC/IF: 1/250 - 1/500.

Alternative Names

SIN3A; SIN3 transcription regulator homolog A (yeast); SIN3 homolog A, transcription regulator (yeast); paired amphipathic helix protein Sin3a; DKFZP434K2235; KIAA0700; transcriptional regulator, SIN3A; transcriptional corepressor Sin3a; transcriptional c

Entrez Gene ID

UniProt ID

Antigen Description

Acts as a transcriptional repressor. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Also interacts with MAD-MAX heterodimers by binding to MAD. The heterodimer then represses transcription by tethering SIN3A to DNA. Acts as a corepressor for REST.

Pathway

Androgen Receptor Signaling Pathway, organism-specific biosystem; C-MYB transcription factor network, organism-specific biosystem; Delta-Notch Signaling Pathway, organism-specific biosystem; EGFR1 Signaling Pathway, organism-specific biosystem; Factors involved in megakaryocyte development and platelet production, organism-specific biosystem; Fatty acid, triacylglycerol, and ketone body metabolism, organism-specific biosystem; Hedgehog Signaling Pathway, organism-specific biosystem;