Anti-SIGLEC1 monoclonal antibody

Antibody Isotype

IgG2a

Clone

FE4

Species Reactivity

Rat

Immunogen

Rat Spleen cell homogenate

Conjugate

Unconjugated

Application Notes

Flow Cyt: 1/500; Immunohistology - Frozen: 1/50 - 1/250

Alternative Names

SIGLEC1; sialic acid binding Ig-like lectin 1, sialoadhesin; Sn; sialoadhesin

Entrez Gene ID

311426

UniProt ID

D3ZVM6

Antigen Description

Sialoadhesin is a cell adhesion molecule found on the surface of certain cells of the immune system called macrophages. It is found in especially high amounts on macrophages of the spleen, liver, lymph node, bone marrow, colon, and lungs. Also, in patients suffering from rheumatoid arthritis, the protein has been found in great amounts on macrophages of the affected tissues. It is defined as an I-type lectin, since it contains 17 immunoglobulin (Ig) domains (one variable domain and 16 constant domains), and thus also belongs to the immunoglobulin superfamily (IgSF). Sialoadhesin binds to certain molecules called sialic acids. During this binding process a salt bridge (protein) is formed between a highly conserved arginine residue (from the v-set domain to the 3'-sialyllactose) and the carboxylate group of the sialic acid. Since sialoadhesin binds sialic acids with its N-terminal IgV-domain, it is also a member of the SIGLEC family. Alternate names for sialoadhesin include siglec-1 and CD169 (cluster of differentiation 169).

Pathway

Adaptive Immune System; Allograft rejection; Autoimmune thyroid disease; CD28 co-stimulation; CD28 dependent PI3K/Akt signaling; CD28 dependent Vav1 pathway; CTLA4 inhibitory signaling; Cell adhesion molecules (CAMs); Constitutive PI3K/AKT Signaling in Cancer; Costimulation by the CD28 family; DAP12 interactions; DAP12 signaling; Disease; Downstream Signaling Events Of B Cell Receptor (BCR); Downstream signal transduction; Downstream signaling of activated FGFR; Fc epsilon receptor (FCERI) signa

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