Anti-SIGLEC1 monoclonal antibody (CABT-35767MH)

Mouse anti-Human SIGLEC1 monoclonal antibody for ELISA, FC, ICC/IF, IHC-Fr, IHC-P, RIA, WB Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgG1
Clone
ITo 8E3
Species Reactivity
Human
Immunogen
Full length hSn(d1-4)Fc protein (purified) (Human).
Conjugate
Unconjugated

Applications


Application Notes
WB 1/250
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Target


Alternative Names
SIGLEC1; sialic acid binding Ig-like lectin 1, sialoadhesin; sialoadhesin , SN; sialoadhesin; CD169; dJ1009E24.1
Entrez Gene ID
UniProt ID

Product Background


Gene summary
SIGLEC1 (Sialic Acid Binding Ig Like Lectin 1) is a Protein Coding gene. Diseases associated with SIGLEC1 include kaposi sarcoma and diffuse cutaneous systemic sclerosis. Among its related pathways are Immune System and Cell adhesion molecules (CAMs). GO annotations related to this gene include carbohydrate binding. An important paralog of this gene is CD22. This gene encodes a member of the immunoglobulin superfamily. The encoded protein is a lectin-like adhesion molecule that binds glycoconjugate ligands on cell surfaces in a sialic acid-dependent manner. It is a type I transmembrane protein expressed only by a subpopulation of macrophages and is involved in mediating cell-cell interactions. Alternative splicing produces a transcript variant encoding an isoform that is soluble rather than membrane-bound; however, the full-length nature of this variant has not been determined.
Antigen Description
The product of this gene belongs to the family of RAS-related proteins. These proteins share approximately 50% amino acid identity with the classical RAS proteins and have numerous structural features in common. The most striking difference between RAP proteins and RAS proteins resides in their 61st amino acid: glutamine in RAS is replaced by threonine in RAP proteins. The product of this gene counteracts the mitogenic function of RAS because it can interact with RAS GAPs and RAF in a competitive manner. Two transcript variants encoding the same protein have been identified for this gene. Acts as an endocytic receptor mediating clathrin dependent endocytosis. Macrophage-restricted adhesion molecule that mediates sialic-acid dependent binding to lymphocytes, including granulocytes, monocytes, natural killer cells, B-cells and CD8 T-cells. Preferentially binds to alpha-2,3-linked sialic acid (By similarity). Binds to SPN/CD43 on T-cells (By similarity). May play a role in hemopoiesis. The function about SIGLEC1 antigen include sugar binding.
Pathway
Cell adhesion molecules (CAMs), organism-specific biosystem; Cell adhesion molecules (CAMs), conserved biosystem.

Citations


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References


Satoh, J; Tabunoki, H; et al. Immunohistochemical characterization of microglia in Nasu-Hakola disease brains. NEUROPATHOLOGY 31:363-375(2011).
Malhotra, S; Bustamante, MF; et al. Search for Specific Biomarkers of IFN beta Bioactivity in Patients with Multiple Sclerosis. PLOS ONE 6:-(2011).

Custom Antibody Labeling


We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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