Recombinant fragment corresponding to a region within amino acids 54 and 410 of Human SIGIRR (UniProt ID: Q6IA17).
Conjugate
Unconjugated
Applications
Application Notes
WB: 1/500 - 1/3000; IHC-P: 1/100 - 1/1000.
Target
Alternative Names
SIGIRR; single immunoglobulin and toll-interleukin 1 receptor (TIR) domain; single Ig IL-1-related receptor; single immunoglobulin domain IL1R1 related; TIR8; toll/interleukin-1 receptor 8; single Ig IL-1R-related molecule; single immunoglobulin domain-co
Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain interaction with TLR4. Through its extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP.
Pathway
Activated TLR4 signalling; Immune System; Innate Immune System; MyD88:Mal cascade initiated on plasma membrane; Toll Like Receptor 2 (TLR2) Cascade; Toll Like Receptor 4 (TLR4) Cascade; Toll Like Receptor TLR1:TLR2 Cascade
Citations
Publication ()
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COA
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