Recombinant fragment corresponding to a region within amino acids 54 and 410 of Human SIGIRR (UniProt ID: Q6IA17).
Conjugate
Unconjugated
Applications
Application Notes
WB: 1/500 - 1/3000; IHC-P: 1/100 - 1/1000.
Target
Alternative Names
SIGIRR; single immunoglobulin and toll-interleukin 1 receptor (TIR) domain; single Ig IL-1-related receptor; single immunoglobulin domain IL1R1 related; TIR8; toll/interleukin-1 receptor 8; single Ig IL-1R-related molecule; single immunoglobulin domain-co
Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain interaction with TLR4. Through its extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP.
Pathway
Activated TLR4 signalling; Immune System; Innate Immune System; MyD88:Mal cascade initiated on plasma membrane; Toll Like Receptor 2 (TLR2) Cascade; Toll Like Receptor 4 (TLR4) Cascade; Toll Like Receptor TLR1:TLR2 Cascade
Custom Antibody Labeling
We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More
Citations
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Drexler, SK; Kong, P; et al. SIGIRR/TIR-8 Is an Inhibitor of Toll-like Receptor Signaling in Primary Human Cells and Regulates Inflammation in Models of Rheumatoid Arthritis. ARTHRITIS AND RHEUMATISM 62:2249-2261(2010).
Zhu, YY; Su, Y; et al. The Largely Normal Response to Toll-Like Receptor 7 and 9 Stimulation and the Enhanced Expression of SIGIRR by B Cells in Systemic Lupus Erythematosus. PLOS ONE 7:-(2012).
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COA
Certificate of Analysis
