SI (NP_001032, 1728 a.a. ~ 1826 a.a) partial recombinant protein with GST tag. The sequence is DGESIDTYERDLYLSVQFNLNQTTLTSTILKRGYINKSETRLGSLHVWGKGTTPVNAVTL TYNGNKNSLPFNEDTTNMILRIDLTTHNVTLEEPIEINW
This gene encodes a sucrase-isomaltase enzyme that is expressed in the intestinal brush border. The encoded protein is synthesized as a precursor protein that is cleaved by pancreatic proteases into two enzymatic subunits sucrase and isomaltase. These two subunits heterodimerize to form the sucrose-isomaltase complex. This complex is essential for the digestion of dietary carbohydrates including starch, sucrose and isomaltose. Mutations in this gene are the cause of congenital sucrase-isomaltase deficiency.[provided by RefSeq, Apr 2010]
Pathway
Carbohydrate digestion and absorption; Digestion of dietary carbohydrate; Galactose metabolism; Glycogen storage diseases.
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