Anti-SH3GL1 (aa 12-119) polyclonal antibody

Species Reactivity

Human

Immunogen

SH3GL1 (NP_003016, 12 a.a. ~ 119 a.a) partial recombinant protein with GST tag. The sequence is KASQLVSEKVGGAEGTKLDDDFKEMEKKVDVTSKAVTEVLARTIEYLQPNPASRAKLTML NTVSKIRGQVKNPGYPQSEGLLGECMIRHGKELGGESNFGDALLDAGE

Conjugate

Alternative Names

SH3GL1; SH3-domain GRB2-like 1; EEN; CNSA1; SH3P8; SH3D2B; endophilin-A2; endophilin-2; SH3 domain protein 2B; EEN fusion partner of MLL; extra 11-19 leukemia fusion; SH3-containing Grb-2-like 1 protein; SH3 domain-containing GRB2-like protein 1; extra el

Entrez Gene ID

UniProt ID

Antigen Description

This gene encodes a member of the endophilin family of Src homology 3 domain-containing proteins. The encoded protein is involved in endocytosis and may also play a role in the cell cycle. Overexpression of this gene may play a role in leukemogenesis, and the encoded protein has been implicated in acute myeloid leukemia as a fusion partner of the myeloid-lymphoid leukemia protein. Pseudogenes of this gene are located on the long arm of chromosomes 11 and 17. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Pathway

Endocytosis; Signaling events mediated by focal adhesion kinase;