Anti-SH3GL1 monoclonal antibody (DCABH-412)

Mouse anti-Human SH3GL1 monoclonal antibody for IP, WB, IHC-P, FC, ICC/IF Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgG1
Clone
3G6
Species Reactivity
Human
Immunogen
Recombinant full length Human SH3 containing Grb 2 like 1 protein (NP_003016) produced in HEK293T cells
Conjugate
Unconjugated

Applications


Application Notes
WB: 1/2000; IHC-P: 1/150; Flow Cyt: 1/100; ICC/IF: 1/100;
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Target


Alternative Names
SH3GL1; SH3-domain GRB2-like 1; endophilin-A2; CNSA1; EEN; extra 11 19 leukemia fusion
Entrez Gene ID
UniProt ID

Product Background


Gene summary
SH3GL1 (SH3 Domain Containing GRB2 Like 1) is a Protein Coding gene. Diseases associated with SH3GL1 include lymphoid leukemia and leukemia, acute myeloid. Among its related pathways are Endocytosis and Signaling events mediated by focal adhesion kinase. GO annotations related to this gene include identical protein binding and phosphatase binding. An important paralog of this gene is SH3GLB2. This gene encodes a member of the endophilin family of Src homology 3 domain-containing proteins. The encoded protein is involved in endocytosis and may also play a role in the cell cycle. Overexpression of this gene may play a role in leukemogenesis, and the encoded protein has been implicated in acute myeloid leukemia as a fusion partner of the myeloid-lymphoid leukemia protein. Pseudogenes of this gene are located on the long arm of chromosomes 11 and 17. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Antigen Description
Implicated in endocytosis. May recruit other proteins to membranes with high curvature. Note=In some cases of acute leukemia, a translocation results in the formation of a KMT2A/MLL1-EEN fusion gene. Endophilin-A2 is a protein that in humans is encoded by the SH3GL1 gene. 0The function about SH3GL1 antigen include lipid binding; protein binding.
Pathway
Endocytosis, organism-specific biosystem; Endocytosis, conserved biosystem; Signaling events mediated by focal adhesion kinase, organism-specific biosystem.

Citations


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References


Matsutani, T; Hiwasa, T; et al. Autologous antibody to src-homology 3-domain GRB2-like 1 specifically increases in the sera of patients with low-grade gliomas. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH 31:-(2012).
Matsutani, T; Iwadate, Y; et al. AUTOLOGOUS SH3-DOMAIN GRB2-LIKE 1 (SH3GL1) ANTIBODY AS A NOVEL SERUM MARKER SPECIFIC TO LOW-GRADE GLIOMA. NEURO-ONCOLOGY 11:898-898(2009).

Custom Antibody Labeling


We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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