Synthetic peptide conjugated to KLH, corresponding to a region within internal sequence amino acids 148-177 of Human SH3BGR (NP_001001713.1, NP_031367.1).
SH3BGR gene maps proximal to HMG14 on 21q22.3 and is differentially expressed in heart and skeletal muscle. SH3BGR encodes a 239-amino acid protein characterized by the presence of a proline-rich region containing the consensus sequence for an SH3-binding domain and by an acidic carboxy-terminal region containing a glutamic acid-rich domain predicted to assume a coiled-coil structure. The presence of 2 functional domains involved in protein-protein interactions suggested to the authors that SH3BGR may be part of a multimeric complex.
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