This protein encodes an enzyme that synthesizes selenophosphate from selenide and ATP. Selenophosphate is the selenium donor used to synthesize selenocysteine, which is co translationally incorporated into selenoproteins at in frame UGA codons. This protein itself contains a selenocysteine residue in its predicted active site. The 3 UTR of the gene has a stem loop secondary structure called a selenocysteine insertion sequence (SECIS) element, which allows UGA to direct the incorporation of selenocysteine rather than signal a translational stop.
Pathway
Selenium Metabolism and Selenoproteins; Selenocompound metabolism;
Citations
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