Anti-SEPHS2 (full length) polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human; Mouse

Immunogen

Recombinant protein corresponding to full length mouse Sephs2.

Conjugate

Application Notes

ELISA: 1:5000-1:20000; WB: 1:500-1:2000. & The optimal working dilution should be determined by the end user.

Alternative Names

SEPHS2; selenophosphate synthetase 2; Sps2; Ysg3; selenide, water dikinase 2; clone 1000; the SelD gene product; selenium donor protein 2; selenophosphate synthase 2;

Entrez Gene ID

UniProt ID

Antigen Description

This gene encodes an enzyme that synthesizes selenophosphate from selenide and ATP. Selenophosphate is the selenium donor used to synthesize selenocysteine (Sec) that is co-translationally incorporated into selenoproteins at in-frame UGA codons, which normally signal translation termination. This protein itself contains a Sec residue in its predicted active site. The 3 UTR of this gene has a stem-loop secondary structure called a selenocysteine insertion sequence (SECIS) element, which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal.

Pathway

Selenium metabolism/Selenoproteins; Selenocompound metabolism;