Anti-SCN8A (aa 1854-1951) polyclonal antibody

Species Reactivity

Human

Immunogen

SCN8A (NP_055006, 1854 a.a. ~ 1951 a.a) partial recombinant protein with GST tag. The sequence is RVLGDSGELDILRQQMEERFVASNPSKVSYEPITTTLRRKQEEVSAVVLQRAYRGHLARR GFICKKTTSNKLENGGTHREKKESTPSTASLPSYDSVT

Conjugate

Alternative Names

SCN8A; sodium channel, voltage gated, type VIII, alpha subunit; MED; PN4; CIAT; NaCh6; CERIII; EIEE13; Nav1.6; sodium channel protein type 8 subunit alpha; hNa6/Scn8a voltage-gated sodium channel; voltage-gated sodium channel subunit alpha Nav1.6;

Entrez Gene ID

UniProt ID

Antigen Description

This gene encodes a member of the sodium channel alpha subunit gene family. The encoded protein forms the ion pore region of the voltage-gated sodium channel. This protein is essential for the rapid membrane depolarization that occurs during the formation of the action potential in excitable neurons. Mutations in this gene are associated with mental retardation, pancerebellar atrophy and ataxia. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2010]

Pathway

Axon guidance; Interaction between L1 and Ankyrins;