Anti-SCN2A (aa 273-362) polyclonal antibody

Species Reactivity

Human

Immunogen

SCN2A2 (NP_066287, 273 a.a. ~ 362 a.a) partial recombinant protein with GST tag. The sequence is NLRNKCLQWPPDNSSFEINITSFFNNSLDGNGTTFNRTVSIFNWDEYIEDKSHFYFLEGQ NDALLCGNSSDAGQCPEGYICVKAGRNPNY

Conjugate

Alternative Names

SCN2A; sodium channel, voltage-gated, type II, alpha subunit; HBA; NAC2; BFIC3; BFIS3; BFNIS; HBSCI; EIEE11; HBSCII; Nav1.2; SCN2A1; SCN2A2; Na(v)1.2; sodium channel protein type 2 subunit alpha; HBSC II; voltage-gated sodium channel subtype II; sodium ch

Entrez Gene ID

UniProt ID

Antigen Description

Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit with 24 transmembrane domains and one or more regulatory beta subunits. They are responsible for the generation and propagation of action potentials in neurons and muscle. This gene encodes one member of the sodium channel alpha subunit gene family. It is heterogeneously expressed in the brain, and mutations in this gene have been linked to several seizure disorders. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.

Pathway

Axon guidance; Interaction between L1 and Ankyrins;