Anti-SAG polyclonal antibody

BACKGROUND: Intracranial hypotension (IH) has a widely variable clinical and radiologic presentation. Secondary IH may be caused by degenerative spine disorders and in particular by thoracic disk herniations (TDHs). METHODS: We present 2 patients with a transdural TDH, a secondary IH, and superficial siderosis in 1. RESULTS: Case 1 presented with headache, cognitive decline, staggering gait, bilateral subdural effusions, cerebral sagging, an extradural spinal cerebrospinal fluid (CSF) collection suggesting secondary IH, and a calcified TDH at T9-T10. Case 2 presented with intermittent pain at the craniocervical junction provoked exclusively by specific physical activities, superficial siderosis mainly in the posterior fossa, an extradural spinal CSF collection, and a calcified TDH at T7-T8 yet no intracranial signs of IH. In both cases, using strict thoracoscopic technique, we removed a transdural TDH and reconstructed an underlying longitudinal slitlike dural defect with smooth lining. Follow-up magnetic resonance imaging scans confirmed a dramatically improved situation without residual extradural intraspinal CSF collection or signs of IH. CONCLUSIONS: This paper adds to the evidence that some cases of IH and even superficial siderosis are caused by transdural erosion of a TDH that may be otherwise asymptomatic. The dura may degenerate due to chronic compression, and a longitudinal slitlike dural defect with smooth lining may develop, causing continuous (Case 1) or intermittent (Case 2) intraspinal CSF leakage. To the best of our knowledge, such dural defects closely resembling the ones observed in idiopathic spinal cord herniation have never been demonstrated on intraoperative endoscopic video in IH patients.

Instead of a monolayer, multi-layered cushion can be promising to develop more comfortable automotive seat if the layer materials are properly selected. In this study, we have examined the seating comfort of different types of multilayer seat cushions. Polyurethane foams (PUFs) of three different hardness, memory foam, and technogel were used in different combination to prepare four types of multilayer seat cushions. The short-term seating comfort of the seat cushions has been investigated in terms of hardness, initial hardness factor (IHF), modulus irregularity factor (MIF), sag factor (SF), and hysteresis loss as derived from the indentation force deflection (IFD) curves. Long-term comfort has been compared to the respective stress relaxation behavior of the seat cushions. It has been observed that both the short and long-term conditions of comfort are not only influenced by the characteristics of the upper layer, but also by the bottom layer (i.e., supporting material). The present work will help the seat designer to consider the material characteristics for fabricating a good automotive seat on the basis of the desired features needed to provide traveling passengers with proper short- and long-term comfort.