Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. Is coupled to both the G(i/0)alpha and G(12) subclass of heteromeric G-proteins (By similarity). May play a regulatory role in the transformation of radial glial cells into astrocytes and may affect proliferative activity of these cells.
Pathway
Class A/1 (Rhodopsin-like receptors); GPCR downstream signaling; Lysosphingolipid and LPA receptors; Neuroactive ligand-receptor interaction
Citations
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