Synthetic peptide RNLQSRWRSPSHEN (with a Cysteine residue linker) from the C terminal amino acids 2458-2470 of Human Rif1 (NP_060621.3; NP_001171134.1).
Conjugate
Unconjugated
Applications
Application Notes
WB, ELISA, IF Each laboratory should determine an optimum working titer for use in its particular application. Other applications have not been tested but use in such assays should not necessarily be excluded.
Required for checkpoint mediated arrest of cell cycle progression in response to DNA damage during S-phase (the intra-S-phase checkpoint). This checkpoint requires activation of at least 2 parallel pathways by the ATM kinase: one involves the MRN (MRE11A-RAD50-NBS1) complex, while the second requires CHEK2. RIF1 seems to act independently of both these pathways. Seems to play no role in either the G1/S or G2/M DNA damage checkpoints.
Citations
Publication ()
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