This product (Catalog No. DPABH-28553) is a rabbit-derived polyclonal antibody raised against human RIF1, targeting the amino acid region 2277–2472 of the protein. This antibody exhibits cross-reactivity with Human RIF1 from mouse. It has been affinity purified by Protein A. RIF1 (Rap1-interacting factor 1) is a multifunctional chromosome stability protein implicated in controlling DNA replication and repair. Human RIF1 can interact with protein phosphatase 1 (PP1) and the interaction is crucial for controlling DNA replication by limiting phosphorylation of the MCM complex (PMID: 28077461). RIF1 also acts with PP1 to protect nascent DNA from overdegradation at stalled replication forks (PMID: 31141682). RIF1 promotes non-homologous end joining (NHEJ) in double strand break (DSB) repair (PMID: 30443189). Research studies show that RIF1 is overexpressed in breast cancer tissues and is upgraded in NSCLC tissues (PMID: 30237512). DPABH-28553 is suitable for use in Western blot (WB) (1:1,000–1:4,000), IHC (1:400–1:1,600), IF/ICC (1:600–1:2,400) applications. DPABH-28553 is supplied as a liquid formulation in PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.
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